Prescript Assist Is a Risky Supplement

What is Prescript Assist?

Prescript Assist is a popular probiotic supplement in the ancestral health community because it is marketed as following ancestral principles. The claim is that this product contains microorganisms found in soil, which are “natural” and what our ancestors consumed with their unwashed produce. Some of the claims of this product are the following:

  • It can survive the harsh conditions of the gastrointestinal tract

  • It can colonize the gut

  • It has beneficial organisms in it

  • It has clinical evidence behind it

  • The product has prebiotics that will feed the bacteria in the product

Wow! The product seems like a miracle that addresses so many difficulties encountered by lactic-acid bacteria probiotics. The old Prescript Assist formula had 29 species of “soil-based organisms,” the new formula has 28, with several new species replacing old ones. Here are some of the microbes that are included in it:

Old Formula New Formula
Arthrobacter agilis Arthobacter globiformis
Arthrobacter citreus Azospirillum brasilense
Arthrobacter globiformis Azosprillum lipoferum
Arthrobacter luteus Azotobacter chroococcum
Arthrobacter simplex Azotobacter paspali
Acinetobacter calcoaceticus Azotobacter vinelandii
Azotobacter chroococcum Bacillus amyloliquefaciens
Azotobacter paspali Bacillus atrophaeus
Azospirillum brasiliense Bacillus licheniformis
Azospirillum lipoferum Bacillus megaterium
Bacillus brevis Bacillus pumilus
Bacillus macerans Bacillus subtilis
Bacillus pumilus Bacillus thuringiensis
Bacillus polymyxa Bacillus firmus
Bacillus subtilis Brevibacillus brevis
Bacteroides lipolyticum Cellulomonas fimi
Bacteriodes succinogene Kurthia zopfii
Brevibacterium lipolyticum Micrococcus luteus
Brevibacterium stationis Nocardioides simplex
Kurthia zopfii Pseudomonas fluorescens
Myrothecium verrucaria Pseudomonas putida
Pseudomonas calcis Rhodobacter sphaeroides
Pseudomonas dentrificans Rhodococcus rhodochrous
Pseudomonas fluorescens Rhodopseudomonas palustris
Pseudomonas glathei Rhodospirillum rubrum
Phanerochaete chrysosporium Streptomyces griseus
Streptomyces fradiae Streptomyces griseoflavus
Streptomyces cellulosae Streptomyces venezuelae
Streptomyces griseoflavus

Let’s first explore whether it makes any sense to include these strains in a probiotic supplement. Some questions to consider:

  • Are these microorganisms found in the human GI tract?

  • Are these microbes found in foods that humans regularly eat?

  • How do these microbes interact with each other?

  • How do these microbes interact with human microbes? Will they produce antibiotics that could kill human bacteria?

  • What effects will they have on the immune system? Are they safe?

  • Have been they tested in large human studies, what about animal models?

  • Have they been tested over long periods of time?

Let’s do some investigative research. Searches of MEDLINE, the database of studies that are searchable using the search engine PubMed yield almost no human or animal results for several of these microorganisms.

In fact, a lot of these organisms are used for agricultural and industrial purposes. Also, it’s interesting that several of the species found in Prescript Assist are not found in human or animal studies but are found in this fertilizer product by Tainio Biologicals. Look at the italicized ingredients…

So Prescript Assist is literally repackaged soil fertilizer!

Also, several of the listed species above are known to produce antibiotics. One thing to consider is that if these organisms are spore-forming, antibiotic-producing bacteria, then it’s very possible that several of them (the clear majority in this product, which have not been studied) are competing with microorganisms in the gut for resources.

The Clinical Evidence

However, the old formulation claims to be tested in a clinical trial and claims to be beneficial for symptoms of IBS. In fact, most of the paleo community has promoted the product because of this clinical evidence. Let’s look at this study.

Here are the positives of this study

  • A randomized trial with a placebo as a control

  • Double-blinded

  • Used a repeated-measures ANCOVA for data analysis (this increases the precision of the data)

Real limitations

  • Only two weeks long

  • Had 26 participants

  • Used an IBS questionnaire that is not validated

  • Atrocious reporting of the study (then again, it’s an old study, so it’s somewhat understandable)

A randomized trial with 26 participants, that’s only two weeks long should not be used to market a product. There is a reason drugs and interventions must go through extensive testing before they’re allowed to be marketed as being effective for a condition/disease. Small sample sizes have lots of variability in the data and give imprecise results. And with something like the microbiome, a two-week study does not justify the safety of this product. It’s also one study. No conclusions should ever be drawn from a single trial!

Yet, several health gurus have been affiliates for this product and were hesitant to recommend the new formulation because it didn’t have the clinical evidence to back it, however, the clinical evidence to back the product in the first place was never strong!

Are Probiotics a Waste of Money?

Various probiotic supplements have been studied for several conditions. Some of them have shown promise, most of them have not. If you want to see some of this research, look at my comprehensive table here, where I gather high-quality systematic reviews on probiotic supplementation.

A note: If you’re going to ingest microorganisms to improve your health, you want to make sure that they’re safe and that they’ve been tested rigorously in human trials. If you’re going to be a bit more cutting edge because you’re desperate, you may at least want to be sure that the theory behind what you’re ingesting is sound.

For example, probiotics with lactic acid bacteria are found in fermented foods, like yogurt, which seem to be linked with improved digestive outcomes. They’ve been studied in in-vitro studies (petri dishes), in animal models, and in humans, and have been found to be relatively safe.

However, putting random organisms from the soil (a vast ecosystem, with who knows how many bacteria, doesn’t seem like a good idea). Especially when there’s no evidence to suggest these will help.

See also

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